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Could AI and Automation Find Better Treatments for Cancer - and Maybe Aging?

Slashdot.org - Sat, 04/19/2025 - 17:34
CNN looks at "one field that's really benefitting" from the use of AI: "the discovery of new medicines". The founder/CEO of London-based LabGenius says their automated robotic system can assemble "thousands of different DNA constructs, each of which encodes a completely unique therapeutic molecule that we'll then test in the lab. This is something that historically would've had to have been done by hand." In short, CNN says, their system lets them "design and conduct experiments, and learn from them in a circular process that creates molecular antibodies at a rate far faster than a human researcher." While many cancer treatments have debilitating side effects, CNN notes that LabGenius "reengineers therapeutic molecules so they can selectively target just the diseased cells." But more importantly, their founder says they've now discovered "completely novel molecules with over 400x improvement in [cell] killing selectivity." A senior lecturer at Imperial College London tells CNN that LabGenius seems to have created an efficient process with seamless connections, identifying a series of antibodies that look like they can target cancer cells very selectively "that's as good as any results I've ever seen for this." (Although the final proof will be what happens when they test them on patients..) "And that's the next step for Labgenius," says CNN. "They aim to have their first therapeutics entering clinics in 2027." Finally, CNN asks, if it succeeds is their potential beyond cancer treatment? "If you take one step further," says the company's CEO/founder, "you could think about knocking out senescent cells or aging cells as a way to treat the underlying cause of aging."

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Curiosity Rover Finds Hints of a Carbon Cycle on Ancient Mars

Slashdot.org - Sat, 04/19/2025 - 16:34
Billions of years ago Mars "had a warm, habitable climate with liquid water in lakes and flowing rivers," writes Ars Technica. But "In order for Mars to be warm enough to host liquid water, there must have been a lot of carbon dioxide in the atmosphere," says Benjamin Tutolo, a researcher at the University of Calgary. "The question we've been asking for at least 30 years was where the record of all this carbon is." Tutolo led a new study of rock samples collected by the Curiosity rover that might have answered this question... Curiosity rover was called Mars Science Laboratory for a reason. It went to the red planet fitted with a suite of instruments, some of which even the newer Perseverance was lacking. These enabled it to analyze the collected Martian rocks on the spot and beam the results back to Earth. "To get the most bang for the buck, NASA decided to send it to the place on Mars called the Gale Crater, because it was the tallest stack of sediments on the planet," Tutolo says. The central peak of Gale Crater was about 5 kilometers tall, created by the ancient meteorite impact... The idea then was to climb up Mount Sharp and collect samples from later and later geological periods at increasing elevations, tracing the history of habitability and the great drying up of Mars. On the way, the carbon missed by the satellites was finally found... It turned out the samples contained roughly between 5 and 10 percent of siderite... The siderite found in the samples was also pure, which Tutolo thinks indicates it has formed through an evaporation process akin to what we see in evaporated lakes on Earth. This, in turn, was the first evidence we've found of the ancient Martian carbon cycle. "Now we have evidence that confirms the models," Tutolo claims. The carbon from the atmosphere was being sequestered in the rocks on Mars just as it is on Earth. The problem was, unlike on Earth, it couldn't get out of these rocks... A large portion of carbon that got trapped in Martian rocks stayed in those rocks forever, thinning out the atmosphere. "While it's likely the red planet had its own carbon cycle, it was an imperfect one that eventually turned it into the lifeless desert it is today," the article points out. But the study still doesn't entirely explain what warmed the atmosphere of Mars — or why Martian habitability "was seemingly intermittent and fluctuating".

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High School Student Discovers 1.5M New Astronomical Objects by Developing an AI Algorithm

Slashdot.org - Sat, 04/19/2025 - 15:34
For combining machine learning with astronomy, high school senior Matteo Paz won $250,000 in the Regeneron Science Talent Search, reports Smithsonian magazine: The young scientist's tool processed 200 billion data entries from NASA's now-retired Near-Earth Object Wide-field Infrared Survey Explorer (NEOWISE) telescope. His model revealed 1.5 million previously unknown potential celestial bodies.... [H]e worked on an A.I. model that sorted through the raw data in search of tiny changes in infrared radiation, which could indicate the presence of variable objects. Working with a mentor at the Planet Finder Academy at Caltech, Paz eventually flagged 1.5 million potential new objects, accoridng to the article, including supernovas and black holes. And that mentor says other Caltech researchers are using Paz's catalog of potential variable objects to study binary star systems. Thanks to long-time Slashdot reader schwit1 for sharing the article.

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CA/Browser Forum Votes for 47-Day Cert Durations By 2029

Slashdot.org - Sat, 04/19/2025 - 14:34
"Members of the CA/Browser Forum have voted to slash cert lifespans from the current one year to 47 days," reports Computerworld, "placing an added burden on enterprise IT staff who must ensure they are updated." In a move that will likely force IT to much more aggressively use web certificate automation services, the Certification Authority Browser Forum (CA/Browser Forum), a gathering of certificate issuers and suppliers of applications that use certificates, voted [last week] to radically slash the lifespan of the certificates that verify the ownership of sites. The approved changes, which passed overwhelmingly, will be phased in gradually through March 2029, when the certs will only last 47 days. This controversial change has been debated extensively for more than a year. The group's argument is that this will improve web security in various ways, but some have argued that the group's members have a strong alternative incentive, as they will be the ones earning more money due to this acceleration... Although the group voted overwhelmingly to approve the change, with zero "No" votes, not every member agreed with the decision; five members abstained... In roughly one year, on March 15, 2026, the "maximum TLS certificate lifespan shrinks to 200 days. This accommodates a six-month renewal cadence. The DCV reuse period reduces to 200 days," according to the passed ballot. The next year, on March 15, 2027, the "maximum TLS certificate lifespan shrinks to 100 days. This accommodates a three-month renewal cadence. The DCV reuse period reduces to 100 days." And on March 15, 2029, "maximum TLS certificate lifespan shrinks to 47 days. This accommodates a one-month renewal cadence. The DCV reuse period reduces to 10 days." The changes "were primarily pushed by Apple," according to the article, partly to allow more effective reactions to possible changes in cryptography. And Apple also wrote that the shift "reduces the risk of improper validation, the scope of improper validation perpetuation, and the opportunities for misissued certificates to negatively impact the ecosystem and its relying parties." Thanks to Slashdot reader itwbennett for sharing the news.

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Brain Implant Cleared by America's FDA to Help Paralysis Patients

Slashdot.org - Sat, 04/19/2025 - 13:34
An anonymous reader shared this report from CNBC: Neurotech startup Precision Neuroscience on Thursday announced that a core component of its brain implant system has been approved by the U.S. Food and Drug Administration, a major win for the four-year-old company... The company's brain-computer interface will initially be used to help patients with severe paralysis restore functions such as speech and movement, according to its website. Only part of Precision's system was approved by the FDA on Thursday, but it marks the first full regulatory clearance granted to a company developing a wireless BCI, Precision said in a release. Other prominent startups in the space include Elon Musk's Neuralink, and Synchron, which is backed by Amazon founder Jeff Bezos and Microsoft co-founder Bill Gates.... The piece of Precision's system that the FDA approved is called the Layer 7 Cortical Interface. The microelectrode array is thinner than a human hair and resembles a piece of yellow scotch tape. Each array is made up of 1,024 electrodes that can record, monitor and stimulate electrical activity on the brain's surface. When it is placed on the brain, Precision says it can conform to the surface without damaging any tissue. The FDA authorized Layer 7 to be implanted in patients for up to 30 days, and Precision will be able to market the technology for use in clinical settings. This means surgeons will be able to use the array during procedures to map brain signals, for instance. It is not Precision's end goal for the technology, but it will help the company generate revenue in the near term. Precision's co-founder and chief science officer also helped co-found Musk's Neuralink in 2017 before departing the following year, according to the article. He nows says this regulatory clearance "will exponentially increase our access to diverse, high-quality data, which will help us to build BCI systems that work more effectively."

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Arch Linux Is the Latest Distro Replacing Redis with Valkey

Slashdot.org - Sat, 04/19/2025 - 12:34
In NoSQL database news, Arch Linux "is the latest Linux distribution replacing its Redis packages with the Valkey fork," reports Phoronix. Valkey is backed by the Linux Foundation, Google, Amazon Web Services, and Oracle, which the article points out is due to Redis's decision last year to shift the upstream Redis license from a BSD 3-clause to RSALv2 and SSPLv1. Valkey is replacing Redis in the Arch Linux extra repository and after a two week period the Redis package will be moved out to AUR and receive no further updates. Users are encouraged to migrate to Valkey as soon as possible.

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As Russia and China 'Seed Chatbots With Lies', Any Bad Actor Could Game AI the Same Way

Slashdot.org - Sat, 04/19/2025 - 11:34
"Russia is automating the spread of false information to fool AI chatbots," reports the Washington Post. (When researchers checked 10 chatbots, a third of the responses repeated false pro-Russia messaging.) The Post argues that this tactic offers "a playbook to other bad actors on how to game AI to push content meant to inflame, influence and obfuscate instead of inform," and calls it "a fundamental weakness of the AI industry." Chatbot answers depend on the data fed into them. A guiding principle is that the more the chatbots read, the more informed their answers will be, which is why the industry is ravenous for content. But mass quantities of well-aimed chaff can skew the answers on specific topics. For Russia, that is the war in Ukraine. But for a politician, it could be an opponent; for a commercial firm, it could be a competitor. "Most chatbots struggle with disinformation," said Giada Pistilli, principal ethicist at open-source AI platform Hugging Face. "They have basic safeguards against harmful content but can't reliably spot sophisticated propaganda, [and] the problem gets worse with search-augmented systems that prioritize recent information." Early commercial attempts to manipulate chat results also are gathering steam, with some of the same digital marketers who once offered search engine optimization — or SEO — for higher Google rankings now trying to pump up mentions by AI chatbots through "generative engine optimization" — or GEO. Our current situation "plays into the hands of those with the most means and the most to gain: for now, experts say, that is national governments with expertise in spreading propaganda." Russia and, to a lesser extent, China have been exploiting that advantage by flooding the zone with fables. But anyone could do the same, burning up far fewer resources than previous troll farm operations... In a twist that befuddled researchers for a year, almost no human beings visit the sites, which are hard to browse or search. Instead, their content is aimed at crawlers, the software programs that scour the web and bring back content for search engines and large language models. While those AI ventures are trained on a variety of datasets, an increasing number are offering chatbots that search the current web. Those are more likely to pick up something false if it is recent, and even more so if hundreds of pages on the web are saying much the same thing... The gambit is even more effective because the Russian operation managed to get links to the Pravda network stories edited into Wikipedia pages and public Facebook group postings, probably with the help of human contractors. Many AI companies give special weight to Facebook and especially Wikipedia as accurate sources. (Wikipedia said this month that its bandwidth costs have soared 50 percent in just over a year, mostly because of AI crawlers....) Last month, other researchers set out to see whether the gambit was working. Finnish company Check First scoured Wikipedia and turned up nearly 2,000 hyperlinks on pages in 44 languages that pointed to 162 Pravda websites. It also found that some false information promoted by Pravda showed up in chatbot answers. "They do even better in such places as China," the article points out, "where traditional media is more tightly controlled and there are fewer sources for the bots." (The nonprofit American Sunlight Project calls the process "LLM grooming".) The article quotes a top Kremlin propagandist as bragging in January that "we can actually change worldwide AI."

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Engineers Want To Bring Home the World's Oldest Satellite

Slashdot.org - Sat, 04/19/2025 - 10:34
Launched in 1958, the "awkward-looking" Vanguard-1 satellite ("the size of a grapefruit") is the oldest artificial object orbiting Earth. "A team of researchers and engineers want to retrieve the satellite for closer inspection and are currently working to find a way to bring Vanguard-1 home," writes Gizmodo: Other satellites of its time have reentered through Earth's atmosphere, burning up in a fiery death, but Vanguard-1 is still in orbit, silently zooming through the void of space... A team of researchers and engineers from Virginia-based consulting firm Booz Allen Hamilton have put together a proposal on how to retrieve the satellite from space, bringing it back to Earth to study how its equipment has fared over the years, according to a report by Space.com. The team's proposal is detailed in a study published in the Aerospace Research Center earlier this year... Considering how old Vanguard-1 is, the astronauts would need to handle it with care, according to the team behind the proposal. Before a retrieval attempt, the team suggests that a spacecraft be sent to rendezvous with the satellite to inspect its condition up-close. The engineers suggested partnering with a wealthy space enthusiast willing to fund the outer space venture, or using a SpaceX vehicle to bring the satellite home. Once it's brought back to Earth, experts would examine Vanguard-1 to assess its condition — whether it was struck by space debris, if it's still holding together, and how its time in orbit has affected the satellite. The satellite could then be placed at the Smithsonian for display as a sort of time capsule, a reminder of the history of spaceflight, the team suggests. "Future missions (space debris removal, materials capture for on-orbit manufacturing, and even deep space exploration) could build on techniques demonstrated in the retrieval of Vanguard 1," the paper read. "Retrieving Vanguard 1 would be a challenge, but an achievable and invaluable step forward for the entire U.S. space community." "The researchers suggest that the satellite can be placed in a lower orbit and snagged from space, or reeled into the International Space Station," according to the article. Space.com shares this assessment from Bill Raynor, the associate superintendent of the Naval Research Laboratory's spacecraft engineering division. "For material and radiation effects scientists and engineers, it would be an unprecedented opportunity for investigating the effects of long-term space environmental exposure." Thanks to long-time Slashdot reader AmiMoJo for sharing the news.

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Trump-Branded 'Lab Leak' Page Replaces US Covid Information Sites

Slashdot.org - Sat, 04/19/2025 - 09:34
"There has never been a consensus or a 'smoking gun' to explain what started the pandemic," writes ABC News. Yet the Associated Press reports that "A federal website that used to feature information on vaccines, testing and treatment for COVID-19 has been transformed into a page supporting the theory that the pandemic originated with a lab leak." (This despite the fact that "about 325 Americans have died from COVID per week on average over the past four weeks, according to the U.S. Centers for Disease Control and Prevention.") The covid.gov website shows a photo of President Donald Trump walking between the words "lab" and "leak" under a White House heading... The web page also accuses Dr. Anthony Fauci, the former director of the National Institute of Allergy and Infectious Diseases, of pushing a "preferred narrative" that COVID-19 originated in nature. The origins of COVID have never been proven. Scientists are unsure whether the virus jumped from an animal, as many other viruses have, or came from a laboratory accident. A U.S. intelligence analysis released in 2023 said there is insufficient evidence to prove either theory. "Many scientists think it's more likely the virus originated naturally in a wild animal and then spilled over into people in a wildlife market located in Wuhan," reports NPR. And even Jamie Metzl, a critic of the wildlife spillover theory, told NPR that while they appreciated "efforts to dig deeper... it would be a terrible shame if such efforts distracted from essential work to help prevent further infections and treat people suffering from COVID-19 and long COVID." (The federal website covidtests.gov now also redirects instead to the new page...) Some scientists were critical of the new site, which they say appears political in intent. "Every one of the five pieces of evidence supporting the lab leak hypothesis ... is factually incorrect, embellished, or presented in a misleading way," [wrote Angela Rasmussen, a virologist at the University of Saskatchewan in Canada]. "But making evidence-based arguments in good faith about the pandemic's origin is not the purpose of this document. This is pure propaganda, intended to justify the systematic devastation of the federal government, particularly programs devoted to public health and biomedical research," Rasmussen added. Other scientists said the web site doesn't follow the existing body of scientific evidence on the issue. That evidence does not support "any of the many, often contradictory, lab leak scenarios that have been proposed," Michael Worobey, an evolutionary biologist at the University of Arizona, in an email to NPR. He argued that the evidence is consistent with "the less flashy hypothesis that bringing live animals infected with pathogens with pandemic potential into the heart of one of the biggest cities in the world was how this pandemic started.... the next pathogen with pandemic potential will find us easy pickings if we don't appreciate how risky this sort of 'biosafety level zero' activity is."

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